An ammonium cation with diverse biological activities; has antifungal

Dequalinium (chloride) – 250 mg

Brand:
Cayman
CAS:
522-51-0
Storage:
-20
UN-No:
Non-Hazardous - /

Dequalinium is a quaternary ammonium cation with diverse biological activities.{43478,43479,43480} It has antifungal activity against C. albicans, C. glabrata, and C. krusei (MICs = 0.5-2, 64-256, and 128 μg/ml, respectively), antitrichomonal activity against T. vaginalis (MICs = 28.8-230.4 µg/ml), and antibacterial activity against a panel of aerobic and facultative anaerobic bacteria (MICs = 0.25-256 µg/ml).{43478} Dequalinium inhibits apamin binding to, and net potassium loss mediated by, SKCa channels in guinea pig hepatocytes stimulated by angiotensin II (Item No. 17150).{43479} In vivo, dequalinium (1-10 mg/kg) inhibits primary and recurrent tumor growth in a W163 rat colon carcinoma isograft model.{43480}  

 

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Description

An ammonium cation with diverse biological activities; has antifungal, antitrichomonal, and antibacterial activity; inhibits apamin binding to and net potassium loss mediated by SKCa channels in angiotensin II-stimulated guinea pig hepatocytes; inhibits primary and recurrent tumor growth in a W163 rat colon carcinoma isograft model from 1-10 mg/kg

Formal name: 1,1′-(1,10-decanediyl)bis[4-amino-2-methyl-quinolinium, dichloride

Synonyms:  NSC 166454

Molecular weight: 527.6

CAS: 522-51-0

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Antifungals||Product Type|Biochemicals|Antiparasitics|Antiprotozoals||Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Cancer||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Infectious Disease|Fungal Diseases|Candidiasis||Research Area|Infectious Disease|Parasitic Diseases|Trichomoniasis

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