A secondary bile acid; inhibits TCA-induced spore germination in seven C. difficile strains at 0.2% v/v; inhibits growth and decreases the cytotoxicity of C. difficile culture supernatants to Vero cells at 0.02% v/v; inhibits ionizing radiation-induced p53-dependent transcription in a reporter assay using HCT116 cells at 200 µM; fecal and intestinal tissue levels are increased in a rat model of high-fat diet-induced obesity compared with rats fed a normal diet; increased serum levels have been found in patients with colorectal cancer

Deoxycholic Acid – 10 g

Brand:
Cayman
CAS:
83-44-3
Storage:
-20
UN-No:
Non-Hazardous - /

Deoxycholic acid (DCA) is a secondary bile acid that is formed via microbial transformation of cholic acid (Item No. 20250) in the colon.{54006} It can be conjugated to glycine or taurine (Item No. 27031) to produce glycodeoxycholic acid (GDCA; Item No. 20274) or taurodeoxycholic acid (TDCA; Item No. 15935), respectively, in hepatocytes.{54006,33902,52692} DCA (0.2% v/v) inhibits spore germination induced by taurocholic acid (TCA; Item No. 16215) in seven C. difficile strains, as well as inhibits growth and decreases the cytotoxicity of C. difficile culture supernatants to Vero cells when used at a concentration of 0.02% v/v.{54006} It inhibits ionizing radiation-induced p53-dependent transcription in a reporter assay using HCT116 cells when used at a concentration of 200 µM.{52693} Fecal and intestinal tissue levels of DCA are increased in a rat model of high-fat diet-induced obesity compared with rats fed a normal diet.{54007} Increased serum DCA levels have been found in patients with colorectal cancer.{52694}  

 

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Description

A secondary bile acid; inhibits TCA-induced spore germination in seven C. difficile strains at 0.2% v/v; inhibits growth and decreases the cytotoxicity of C. difficile culture supernatants to Vero cells at 0.02% v/v; inhibits ionizing radiation-induced p53-dependent transcription in a reporter assay using HCT116 cells at 200 µM; fecal and intestinal tissue levels are increased in a rat model of high-fat diet-induced obesity compared with rats fed a normal diet; increased serum levels have been found in patients with colorectal cancer,,

Formal name: (3α,5β,12α)-3,12-dihydroxy-cholan-24-oic acid

Synonyms:  Cholanoic Acid|DCA|NSC 8797

Molecular weight: 392.6

CAS: 83-44-3

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Sterol Lipids||Research Area|Cancer|Cell Signaling|p53 Signaling||Research Area|Cancer|Transcription Factors|p53||Research Area|Endocrinology & Metabolism|Bile Acids & Microbiome||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Obesity||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases

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