A sesquiterpenoid with anticancer activity; decreases viability of A549 cells at 2.5-15 µg/ml; induces apoptosis in A549 cells at 1-10 µg/ml

Dendrobine – 25 mg

Brand:
Cayman
CAS:
2115-91-5
Storage:
-20
UN-No:
Non-Hazardous - /

Dendrobine is a sesquiterpenoid that has been found in D. nobile and has anticancer activity.{46864,46865} It decreases viability of A549 cells when used at concentrations ranging from 2.5 to 15 µg/ml.{46865} It induces apoptosis in A549 cells when used at concentrations ranging from 1 to 10 µg/ml, as well as increases JNK phosphorylation and sensitizes A549 cells to cisplatin (Item No. 13119) at 10 µg/ml. Dendrobine (50 mg/kg per day) reduces tumor growth in an A549 mouse xenograft model with an additive effect when used in combination with cisplatin.  

 

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Description

A sesquiterpenoid with anticancer activity; decreases viability of A549 cells at 2.5-15 µg/ml; induces apoptosis in A549 cells at 1-10 µg/ml, as well as increases JNK phosphorylation and sensitizes A549 cells to cisplatin at 10 µg/ml; reduces tumor growth in an A549 mouse xenograft model at 50 mg/kg per day with an additive effect when used in combination with cisplatin

Formal name: (2aS,4aS,5R,6S,7R,7aS,7bR)-decahydro-1,7b-dimethyl-6-(1-methylethyl)-7,5-(epoxymethano)-1H-cyclopent[cd]indol-9-one

Synonyms:  (–)-Dendrobine

Molecular weight: 263.4

CAS: 2115-91-5

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Terpenes||Research Area|Cancer|Cell Death|Apoptosis

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