Description
A sesquiterpenoid with anticancer activity; decreases viability of A549 cells at 2.5-15 µg/ml; induces apoptosis in A549 cells at 1-10 µg/ml, as well as increases JNK phosphorylation and sensitizes A549 cells to cisplatin at 10 µg/ml; reduces tumor growth in an A549 mouse xenograft model at 50 mg/kg per day with an additive effect when used in combination with cisplatin
Formal name: (2aS,4aS,5R,6S,7R,7aS,7bR)-decahydro-1,7b-dimethyl-6-(1-methylethyl)-7,5-(epoxymethano)-1H-cyclopent[cd]indol-9-one
Synonyms: (–)-Dendrobine
Molecular weight: 263.4
CAS: 2115-91-5
Purity: ≥95%
Formulation: A crystalline solid
Product Type|Biochemicals|Natural Products|Terpenes||Research Area|Cancer|Cell Death|Apoptosis
