A coumestan with diverse biological activities; reduces CCL4- and GaIN-induced cytotoxicity in rat hepatocytes in a dose-dependent manner; inhibits lethal and hemorrhagic activities of C. rhodostoma venom; inhibits anchorage-independent cell growth of MDA-MB-231 breast cancer cells; decreases the number of lung metastases in an MDA-MB-231 xenograft model in nude mice

Demethylwedelolactone – 500 µg

Brand:
Cayman
CAS:
6468-55-9
Storage:
-20
UN-No:
Non-Hazardous - /

Demethylwedelolactone (DWL) is a coumestan, originally isolated from E. alba, with diverse biological activities.{40154,40155,40156,40157} It reduces cytotoxicity induced by CCL4 and galactosamine (GaIN; Item No. 22981) in rat hepatocytes in a dose-dependent manner.{40154} DWL inhibits trypsin with an IC50 value of 3.0 μg/ml in vitro.{40155} It is the major constituent in purified butanolic extracts of E. prostrata which inhibit lethal and hemorrhagic activities of C. rhodostoma venom.{40156} DWL also inhibits anchorage-independent cell growth of MDA-MB-231 breast cancer cells and decreases the number of lung metastases in an MDA-MB-231 xenograft model in nude mice.{40157}  

 

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SKU: 11703 - 500 µg Category:

Description

A coumestan with diverse biological activities; reduces CCL4- and GaIN-induced cytotoxicity in rat hepatocytes in a dose-dependent manner; inhibits lethal and hemorrhagic activities of C. rhodostoma venom; inhibits anchorage-independent cell growth of MDA-MB-231 breast cancer cells; decreases the number of lung metastases in an MDA-MB-231 xenograft model in nude mice

Formal name: 1,3,8,9-tetrahydroxy-6H-benzofuro[3,2-c][1]benzopyran-6-one

Synonyms:  1,3,8,9-Tetrahydroxycoumestan|DWL|Norwedelolactone

Molecular weight: 300.2

CAS: 6468-55-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Cell Biology|Proteolysis|Cytosolic & Secreted Proteases||Research Area|Toxicology

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