An antimycobacterial compound; active against drug-sensitive and -resistant clinical isolates of M. tuberculosis (MIC90s = 0.01194-0.01248 and 0.01221-0.01341 μg/ml

Delamanid – 250 mg

Brand:
Cayman
CAS:
681492-22-8
Storage:
-20
UN-No:
Non-Hazardous - /

Delamanid is an antimycobacterial compound.{46718} It is active against clinical isolates of M. tuberculosis that are susceptible (MIC90s = 0.01194-0.01248 μg/ml) or resistant to rifampicin (Item No. 14423), isoniazid (Item No. 20378), ethambutol (Item No. 23713), and/or streptomycin (Item No. 21211; MIC90s = 0.01221-0.01341 μg/ml). It inhibits the synthesis of methoxy- and keto-mycolic acid in the M. bovis strain BCG (IC50s = 0.036 and 0.021 μg/ml, respectively). Delamanid (0.1, 0.3, and 1 μg/ml) inhibits the growth of the M. tuberculosis strain H37Rv in infected THP-1 cells. It decreases lung bacterial burden in a mouse model of M. tuberculosis infection in a dose-dependent manner.  

 

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SKU: 29697 - 250 mg Category:

Description

An antimycobacterial compound; active against drug-sensitive and -resistant clinical isolates of M. tuberculosis (MIC90s = 0.01194-0.01248 and 0.01221-0.01341 μg/ml, respectively); inhibits the synthesis of methoxy- and keto-mycolic acid in the M. bovis strain BCG (IC50s = 0.036 and 0.021 μg/ml, respectively); inhibits the growth of the M. tuberculosis strain H37Rv in infected THP-1 cells at 0.1, 0.3, and 1 μg/ml; decreases lung bacterial burden in a mouse model of M. tuberculosis infection in a dose-dependent manner

Formal name: (2R)-2,3-dihydro-2-methyl-6-nitro-2-[[4-[4-[4-(trifluoromethoxy)phenoxy]-1-piperidinyl]phenoxy]methyl]-imidazo[2,1-b]oxazole

Synonyms:  OPC-67683

Molecular weight: 534.5

CAS: 681492-22-8

Purity: ≥98%

Formulation: A crystalline solid

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