An alkaloid with diverse biological activities; inhibits LPS-induced secretion of PGE2 in RAW 264.7 mouse macrophages at 30 μM; reduces the upstroke velocity

Dehydroevodiamine (hydrochloride) – 50 mg

Brand:
Cayman
CAS:
111664-82-5
Storage:
-20
UN-No:
Non-Hazardous - /

Dehydroevodiamine is an alkaloid that has been isolated from E. rutaecarpa and has anti-inflammatory, antiarrhythmic, hypotensive, and anti-amnesic biological activities.{37668,37669,37670,37671} It inhibits LPS-induced secretion of prostaglandin E2 (PGE2; Item No. 14010) in RAW 264.7 mouse macrophages when used at a concentration of 30 μM.{37668} Dehydroevodiamine (0.1-0.3 μM) reduces the upstroke velocity, action potential amplitude, and contractile force of electrically-stimulated primary human atrial trabeculae.{37669} In vivo, dehydroevodiamine (10 mg/kg) decreases mean arterial blood pressure (MAP) by approximately 30% in rats.{37670} Dehydroevodiamine (1.5 mg/kg) also inhibits amnesia induced by amyloid-β (25-35) (Item No. 24155) and increases latency to step-through in a passive avoidance test in mice.{37671}  

 

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SKU: 25101 - 50 mg Category:

Description

An alkaloid with diverse biological activities; inhibits LPS-induced secretion of PGE2 in RAW 264.7 mouse macrophages at 30 μM; reduces the upstroke velocity, action potential amplitude, and contractile force of electrically-stimulated primary human atrial trabeculae from 0.1-0.3 μM; decreases MAP by ~30% in rats at 10 mg/kg; inhibits amyloid-β (25-35)-induced amnesia and increases latency to step-through in a passive avoidance test in mice at 1.5 mg/kg

Formal name: 8,14-dihydro-14-methyl-indolo[2′,3′:3,4]pyrido[2,1-b]quinazolin-5(7H)-one, monohydrochloride

Synonyms: 

Molecular weight: 337.8

CAS: 111664-82-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Alkaloids||Research Area|Cardiovascular System|Heart|Arrhythmia||Research Area|Cardiovascular System|Vasculature|Vasodilation||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Neuroscience|Behavioral Neuroscience

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