An oxidized form of ascorbic acid; inhibits hydrogen peroxide-induced cell death in murine astrocytes by approximately 74 and 83% at 0.5 and 1 mM

Dehydroascorbic Acid – 500 mg

Brand:
Cayman
CAS:
490-83-5
Storage:
-20
UN-No:
Non-Hazardous - /

Dehydroascorbic acid is an oxidized form of ascorbic acid (Item No. 14656).{48603} It is obtained through the diet or formed via oxidation of ascorbic acid in the gut and can also be reduced back to ascorbic acid in various cell types. Dehydroascorbic acid (0.5 and 1 mM) inhibits hydrogen peroxide-induced cell death in murine astrocytes by approximately 74 and 83%, respectively.{48604} It also increases glutathione peroxidase (GPX) and glutathione reductase activity and inhibits production of reactive oxygen species (ROS) in hydrogen peroxide-treated astrocytes when used at a concentration of 1 mM. Dehydroascorbic acid (40 and 250 mg/kg) increases cerebral blood flow and reduces infarct volume and mortality in a mouse model of cerebral ischemia-reperfusion injury induced by transient middle cerebral artery occlusion (MCAO) when administered prior to ischemia.{48605} It also reduces infarct volume in a permanent MCAO mouse model when administered pre- or post-ischemia at doses of 250 and 500 mg/kg, respectively.  

 

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Description

An oxidized form of ascorbic acid; inhibits hydrogen peroxide-induced cell death in murine astrocytes by approximately 74 and 83% at 0.5 and 1 mM, respectively; increases GPX and glutathione reductase activity and inhibits ROS production in hydrogen peroxide-treated astrocytes at 1 mM; increases cerebral blood flow and reduces infarct volume and mortality in a mouse model of cerebral ischemia-reperfusion injury induced by transient MCAO when administered prior to ischemia at 40 and 250 mg/kg; reduces infarct volume in a permanent MCAO mouse model when administered pre- or post-ischemia at 250 and 500 mg/kg, respectively

Formal name: L-threo-2,3-hexodiulosonic acid, γ-lactone

Synonyms:  DHAA|L-Dehydroascorbic Acid

Molecular weight: 174.1

CAS: 490-83-5

Purity: ≥95%

Formulation: A crystalline solid

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