An active metabolite of nifedipine; formed when nifedipine is metabolized by CYP3A4 and CYP3A5; inhibits glucose uptake in PC-12 cells (IC50 = 130 μM)

Dehydro Nifedipine – 5 mg

Brand:
Cayman
CAS:
67035-22-7
Storage:
-20
UN-No:
Non-Hazardous - /

Dehydro nifedipine is an active metabolite of nifedipine (Item No. 11106), a calcium channel blocker present in formulations used to treat hypertension and angina.{39341,39342,20226,20230} Dehydro nifedipine is formed when nifedipine is metabolized by the cytochrome P450 (CYP) isomers CYP3A4 and CYP3A5.{39342} Dehydro nifedipine inhibits glucose uptake in PC-12 cells with an IC50 value of 130 μM.{39341}  

 

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SKU: 23229 - 5 mg Category:

Description

An active metabolite of nifedipine; formed when nifedipine is metabolized by CYP3A4 and CYP3A5; inhibits glucose uptake in PC-12 cells (IC50 = 130 μM),

Formal name: 2,6-dimethyl-4-(2-nitrophenyl)-3,5-dimethyl ester 3,5-pyridinedicarboxylic acid

Synonyms:  BAY-b 4759

Molecular weight: 344.3

CAS: 67035-22-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Toxicology|Drug Metabolism|Cytochrome P450||Research Area|Toxicology|Drug Metabolism|Drug Metabolites

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