A bacterial siderophore that chelates iron; used experimentally to inhibit iron-dependent prolyl hydroxylases (EC50 = 17.8 µM)

Deferoxamine (mesylate) – 10 g

Brand:
Cayman
CAS:
138-14-7
Storage:
-20
UN-No:
Non-Hazardous - /

Deferoxamine is a bacterial siderophore that chelates iron.{23098} It is used to experimentally inhibit iron-dependent prolyl hydroxylases (EC50 = 17.8 µM), thus preventing the degradation of isoforms of hypoxia inducible factor during normoxia.{23099,8840,23097} Deferoxamine has applications in diseases that are characterized by high levels of circulating iron, such as thalassemia major.{23096}  

 

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Description

A bacterial siderophore that chelates iron; used experimentally to inhibit iron-dependent prolyl hydroxylases (EC50 = 17.8 µM), thus preventing the degradation of isoforms of HIF during normoxia

Formal name: N4-[5-[[4-[[5-(acetylhydroxyamino)pentyl]amino]-1,4-dioxobutyl]hydroxyamino]pentyl]-N1-(5-aminopentyl)-N1-hydroxy-butanediamide, monomethanesulfonate

Synonyms:  Ba 33112|DFO|DFOM|DFX|NSC 644468

Molecular weight: 656.8

CAS: 138-14-7

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Metal Chelators||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Research Area|Cell Biology|Cell Death|Ferroptosis

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