An iron chelator that binds to iron in a 3:1 (ligand:iron) ratio and has antioxidant and neuroprotective activities; reduces levels of intracellular iron and inhibits lipid peroxidation in primary rat hepatocytes at 200 and 50 µM

Deferiprone – 1 g

Brand:
Cayman
CAS:
30652-11-0
Storage:
-20
UN-No:
Non-Hazardous - /

Deferiprone is an iron chelator that binds to iron in a 3:1 (ligand:iron) ratio and has antioxidant and neuroprotective activities.{42958} It reduces levels of intracellular iron and inhibits lipid peroxidation in primary rat hepatocytes when used at concentrations of 200 and 50 µM, respectively.{42959} Deferiprone reduces cholesterol diet-induced increases in the levels of amyloid-β (1-42) (Aβ42), Aβ40, and the phosphorylation of tau and glycogen synthase kinase-3β (GSK-3β) in the rabbit hippocampus when administered at a dose of 50 mg/kg.{42960} Formulations containing deferiprone have been used in the treatment of thalassemia.  

 

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Description

An iron chelator that binds to iron in a 3:1 (ligand:iron) ratio and has antioxidant and neuroprotective activities; reduces levels of intracellular iron and inhibits lipid peroxidation in primary rat hepatocytes at 200 and 50 µM, respectively; reduces cholesterol diet-induced increases in the levels of Aβ42, Aβ40, and the phosphorylation of tau and GSK-3β in the rabbit hippocampus at 50 mg/kg

Formal name: 3-hydroxy-1,2-dimethyl-4(1H)-pyridinone

Synonyms:  CGP 37391|DN 18001AF

Molecular weight: 139.2

CAS: 30652-11-0

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Metal Chelators||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cell Biology|Cell Death|Ferroptosis||Research Area|Endocrinology & Metabolism||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation

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