An inhibitor of monoamine transporters and OCTs; inhibits plasma membrane monoamine

Decynium-22 – 1 g

Brand:
Cayman
CAS:
977-96-8
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Decynium-22 is an inhibitor of monoamine transporters and organic cation transporters (OCTs).{48740} It inhibits the plasma membrane monoamine, serotonin (5-HT), norepinephrine, and dopamine monoamine transporters (IC50s = 1.1, 7.9, 30, and 12.9 µM, respectively), and OCT2 and OCT3 (IC50s = 10 and 0.2 µM, respectively) in radioligand binding assays. Decynium-22 also inhibits binding of the α1-adrenergic receptor antagonist prazosin (Item No. 15023) in mouse hippocampal homogenates (IC50 = 60 nM).{48741} It decreases the time stress-sensitive Wistar Kyoto, but not stress-resistant Long-Evans, rats spend immobile in the forced swim test, indicating antidepressant-like activity, when administered at doses of 1 and 10 µg/kg.{48742}  

 

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SKU: 29494 - 1 g Category:

Description

An inhibitor of monoamine transporters and OCTs; inhibits plasma membrane monoamine, 5-HT, norepinephrine, and dopamine monoamine transporters (IC50s = 1.1, 7.9, 30, and 12.9 µM, respectively), and OCT2 and OCT3 (IC50s = 10 and 0.2 µM, respectively) in radioligand binding assays; inhibits binding of prazosin in mouse hippocampal homogenates (IC50 = 60 nM); decreases the time stress-sensitive Wistar Kyoto, but not stress-resistant Long-Evans, rats spend immobile in the forced swim test, indicating antidepressant-like activity, at 1 and 10 µg/kg

Formal name: 1-ethyl-2-[(1-ethyl-2(1H)-quinolinylidene)methyl]-quinolinium, monoiodide

Synonyms:  1,1′-Diethyl-2,2′-Cyanine

Molecular weight: 454.4

CAS: 977-96-8

Purity: ≥98%

Formulation: A crystalline solid

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