A 2' deoxy analog of 5-azacytidine which is incorporated into DNA and causes hypomethylation by inhibiting DNA methyltransferases in a concentration-dependent manner; useful in conditions characterized by DNA hypermethylation

Decitabine – 5 mg

Brand:
Cayman
CAS:
2353-33-5
Storage:
-20
UN-No:
Non-Hazardous - /

5-Azacytidine is an analog of cytidine which can be incorporated into DNA, inhibit DNA methyltransferases, and cause hypomethylation of cytosine residues in the absence of any significant mutagenic effects.{18356,18373} Decitabine is a 2’-deoxy analog of 5-azacytidine which similarly causes hypomethylation of DNA by inhibiting DNA methyltransferases in a concentration-dependent manner.{18356,18373,17257} This action is useful in conditions characterized by DNA hypermethylation, as is found in myelodysplastic syndromes.{20547}  

 

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Description

A 2′ deoxy analog of 5-azacytidine which is incorporated into DNA and causes hypomethylation by inhibiting DNA methyltransferases in a concentration-dependent manner; useful in conditions characterized by DNA hypermethylation, as is found in myelodysplastic syndromes

Formal name: 4-amino-1-(2-deoxy-β-D-erythro-pentofuranosyl)-1,3,5-triazin-2(1H)-one

Synonyms:  5-aza-2’-Deoxycytidine|DAC|NSC 127716

Molecular weight: 228.2

CAS: 2353-33-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Methyltransferases||Research Area|Epigenetics, Transcription, & Translation|Writers|DNA/RNA Methylation

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