A medium-chain saturated fatty acid; a non-competitive antagonist at AMPA receptors; selectively reduces glutamate-induced currents in Xenopus oocytes expressing GluA2/3 subunit-containing AMPA receptors (IC50 = 0.52 mM) over those expressing GluA1 (IC50 = 2.09 mM) or GluA1/2 subunits (IC50 = 1.16 mM); inhibits epileptiform activity induced by pentylenetetrazole or low magnesium in rat hippocampal slices; induces contractions in isolated guinea pig duodenum at 1 mM; increases the escape threshold in an orofacial mechanical stimulation test in rats when administered as a 30% topical ointment; plasma levels of decanoic acid are increased in patients with colorectal cancer when compared to patients with breast cancer or ulcerative colitis or without cancer

Decanoic Acid (sodium salt) – 25 g

Brand:
Cayman
CAS:
1002-62-6
Storage:
22
UN-No:
Non-Hazardous - /

Decanoic acid is a medium-chain saturated fatty acid. It is a non-competitive antagonist at AMPA receptors that selectively reduces glutamate-induced currents in Xenopus oocytes expressing GluA2 and GluA3 subunit-containing AMPA receptors (IC50 = 0.52 mM) over those expressing GluA1 (IC50 = 2.09 mM) or GluA1 and GluA2 subunits (IC50 = 1.16 mM).{47639} It inhibits epileptiform activity induced by pentylenetetrazole (Item No. 18682) or low magnesium in rat hippocampal slices. Decanoic acid (1 mM) induces contractions in isolated guinea pig duodenum, an effect that can be blocked by the muscarinic acetylcholine receptor antagonist hyoscine, voltage-gated sodium channel inhibitor tetrodotoxin (Item Nos. 14964 | 14963), or M2 muscarinic acetylcholine receptor antagonist hexamethonium (Item No. 25505).{47640} It increases the escape threshold in an orofacial mechanical stimulation test in rats when administered at a topical dose of 30% in ointment form, indicating analgesic activity.{47644} This effect can be blocked by the muscarinic acetylcholine receptor antagonist methoctramine (Item No. 24317). Plasma levels of decanoic acid are increased in patients with colorectal cancer when compared to patients with breast cancer or ulcerative colitis or without cancer.{47645}  

 

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A medium-chain saturated fatty acid; a non-competitive antagonist at AMPA receptors; selectively reduces glutamate-induced currents in Xenopus oocytes expressing GluA2/3 subunit-containing AMPA receptors (IC50 = 0.52 mM) over those expressing GluA1 (IC50 = 2.09 mM) or GluA1/2 subunits (IC50 = 1.16 mM); inhibits epileptiform activity induced by pentylenetetrazole or low magnesium in rat hippocampal slices; induces contractions in isolated guinea pig duodenum at 1 mM; increases the escape threshold in an orofacial mechanical stimulation test in rats when administered as a 30% topical ointment; plasma levels of decanoic acid are increased in patients with colorectal cancer when compared to patients with breast cancer or ulcerative colitis or without cancer

Formal name: decanoic acid, monosodium salt

Synonyms:  C10:0|Capric Acid|Decylic Acid

Molecular weight: 194.2

CAS: 1002-62-6

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Lipids|Fatty Acids||Research Area|Cancer||Research Area|Lipid Biochemistry|Fatty Acids||Research Area|Neuroscience|Pain Research||Research Area|Neuroscience|Seizure Disorders

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