A mechanism-based

DDMS – 10 mg

Brand:
Cayman
CAS:
206052-03-1
Storage:
-20
UN-No:
Non-Hazardous - /

Biosynthesis of 20-HETE from arachidonic acid by the cytochrome P450 4A (CYP450 4A) isoforms is an important component of vascular homeostasis, especially in renal circulation.{9094} DDMS is a mechanism-based, irreversible inhibitor that has about 10-fold selectivity for the CYP4A2 enzyme which predominantly synthesizes 20-HETE in the mammalian kidney. DDMS administration in whole anesthetized rats (10 mg/kg) largely ablates the hypotension and vasodilation induced by nitric oxide donors such as NONOates.{4522}  

 

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SKU: 10018 - 10 mg Category:

Description

A mechanism-based, irreversible inhibitor of CYP4A2, an enzyme that predominantly synthesizes 20-HETE in the mammalian kidney

Formal name: 12,12-dibromo-N-(methylsulfonyl)-11-dodecenamide

Synonyms:  Dibromo-dodecenyl-methylsulfimide

Molecular weight: 433.2

CAS: 206052-03-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Cytochrome P450||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypotension||Research Area|Cardiovascular System|Vasculature|Vasodilation||Research Area|Lipid Biochemistry|Cytochrome P450 Pathways

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