A selective agonist of mGluR8 (EC50 = 31 nM in AV12-664 cells); inhibits responses of mouse retinal ganglion cells to the withdrawal of light stimuli at 1 µM; significantly reverses catalepsy induced by prolonged haloperidol exposure in rats at 10 nmol

DCPG – 5 mg

Brand:
Cayman
CAS:
201730-11-2
Storage:
-20
UN-No:
Non-Hazardous - /

DCPG is a selective agonist of the class III metabotropic glutamate receptor 8 (mGluR8), with an EC50 value of 31 nM for inhibiting forskolin-stimulated cAMP formation in AV12-664 cells expressing human mGluR8.{38607} It is selective for mGluR8 over other mGluRs (EC50s = >3.5 µM for mGluR1-7). In vitro, DCPG (1 μM) inhibits the responses of mouse retinal ganglion cells to the withdrawal of both bright and dim light stimuli by 68-69% relative to untreated cells.{38606} In vivo, DCPG (10 nmol, i.c.v.) reverses catalepsy induced by prolonged exposure to haloperidol (Item No. 12014) in a rat model of Parkinson’s disease.{38605}  

 

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Description

A selective agonist of mGluR8 (EC50 = 31 nM in AV12-664 cells); inhibits responses of mouse retinal ganglion cells to the withdrawal of light stimuli at 1 µM; significantly reverses catalepsy induced by prolonged haloperidol exposure in rats at 10 nmol, i.c.v.

Formal name: 4-[(S)-aminocarboxymethyl]-1,2-benzenedicarboxylic acid

Synonyms:  (S)-3,4-DCPG

Molecular weight: 239.2

CAS: 201730-11-2

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Neuroscience|Neurodegenerative Disorders|Parkinson’s Disease||Research Area|Neuroscience|Ophthalmology

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