An activator of PKCε; activates PKCε with a >7-fold stronger potency over PKCα

DCP-LA – 1 mg

Brand:
Cayman
CAS:
28399-31-7
Storage:
-20
UN-No:
Non-Hazardous - /

DCP-LA is a derivative of linoleic acid (Item No. 90150) and a potent activator of PKCε.{41891} It activates PKCε with a greater than 7-fold stronger potency over PKCα, βI, βII, γ, δ, μ, η, and ζ in a cell-free assay. DCP-LA activates PKC in PC12 cells in a concentration-dependent manner, an effect that is blocked by the PCK inhibitor bisindolylmaleimide I (Item Nos. 13298 | 21180) and a PCKε-selective peptide inhibitor. It decreases intracellular levels of amyloid-β (Aβ) in Neuro2 neuroblastoma cells transfected with human APPSwe/PS1Δ9.{41892} DCP-LA also stimulates hippocampal glutamate release, striatal dopamine release, and hypothalamic serotonin release in rat brain slices in a PKC- and α7-containing nicotinic acetylcholine receptor-dependent manner.{41893} In vivo, DCP-LA (3 mg/kg, i.p.) prevents synaptic loss and amyloid plaque formation and decreases escape latency in the Morris water maze in the 5XFAD transgenic mouse model of Alzheimer’s disease.{41894}  

 

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Description

An activator of PKCε; activates PKCε with a >7-fold stronger potency over PKCα, βI, βII, γ, δ, μ, η, and ζ in a cell-free assay; activates PKC in PC12 cells in a concentration-dependent manner; decreases intracellular levels of Aβ in Neuro2 neuroblastoma cells transfected with human APPSwe/PS1Δ9; stimulates hippocampal glutamate release, striatal dopamine release, and hypothalamic serotonin release in rat brain slices in a PKC- and α7-containing nAChR- dependent manner; prevents synaptic loss and amyloid plaque formation and decreases escape latency in the Morris water maze in the 5XFAD transgenic mouse model of Alzheimer’s disease at 3 mg/kg

Formal name: 2-[(2-pentylcyclopropyl)methyl]-cyclopropaneoctanoic acid

Synonyms:  FR 236924

Molecular weight: 308.5

CAS: 28399-31-7

Purity: ≥95%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Fatty Acids||Product Type|Biochemicals|Small Molecule Activators|Kinases||Research Area|Cell Biology|Cell Signaling||Research Area|Lipid Biochemistry||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease

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