A FFAR1 (GPR40) antagonist that inhibits GPR40-mediated Ca2+ elevations stimulated by linoleic

DC260126 – 1 mg

Brand:
Cayman
CAS:
346692-04-4
Storage:
-20
UN-No:
Non-Hazardous - /

DC260126 is a free fatty acid receptor 1 (FFAR1/GPR40) antagonist that inhibits GPR40-mediated Ca2+ elevations stimulated by linoleic, oleic, palmitoleic, and lauric acid (Item Nos. 90150, 90260, 10009871, and 10006626, respectively) with IC50 values of 6.28, 5.96, 7.07, and 4.58 µM, respectively.{31470} At 10 mg/kg, it has been shown to inhibit glucose-stimulated insulin secretion, to reduce blood insulin levels, to improve insulin sensitivity, and to decrease the rate of pancreatic β-cell apoptosis in obese diabetic db/db mice.{31471}  

 

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Description

A FFAR1 (GPR40) antagonist that inhibits GPR40-mediated Ca2+ elevations stimulated by linoleic, oleic, palmitoleic, and lauric acid with IC50 values of 6.28, 5.96, 7.07, and 4.58 µM, respectively; inhibits glucose-stimulated insulin secretion, reduces blood insulin levels, improves insulin sensitivity, and decreases the rate of pancreatic β-cell apoptosis in obese diabetic db/db mice at 10 mg/kg

Formal name: N-(4-butylphenyl)-4-fluoro-benzenesulfonamide

Synonyms: 

Molecular weight: 307.4

CAS: 346692-04-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes

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