An alkaloid with diverse biological activities; enhances camptothecin-induced cytotoxicity in HeLa cells at 10 µM; inhibits camptothecin-induced autophagy in HeLa

Daurisoline – 25 mg

Brand:
Cayman
CAS:
70553-76-3
Storage:
-20
UN-No:
Non-Hazardous - /

Daurisoline is an alkaloid that has been found in M. dauricum and has diverse biological activities.{46756,46758,46759} It enhances cytotoxicity induced by camptothecin (Item No. 11694) in HeLa cells when used at a concentration of 10 µM.{46756} Daurisoline inhibits camptothecin-induced autophagy in HeLa, A549, and HCT116 cells (IC50s = 74.75, 50.54, and 80.81 μM, respectively). It inhibits ADP-induced aggregation of platelets in isolated rabbit whole blood (IC50 = 100 µM).{46758} Daurisoline prolongs action potential duration (APD) and reduces early afterdepolarizations (EADs) in papillary muscle preparations isolated from hypertrophied rabbit hearts when used at a concentration of 15 µM.{46759}  

 

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SKU: 29628 - 25 mg Category:

Description

An alkaloid with diverse biological activities; enhances camptothecin-induced cytotoxicity in HeLa cells at 10 µM; inhibits camptothecin-induced autophagy in HeLa, A549, and HCT116 cells (IC50s = 74.75, 50.54, and 80.81 μM, respectively); inhibits ADP-induced aggregation of platelets in isolated rabbit whole blood (IC50 = 100 µM); prolongs APD and reduces EADs in papillary muscle preparations isolated from hypertrophied rabbit hearts at 15 µM

Formal name: (1R)-1,2,3,4-tetrahydro-1-[[4-hydroxy-3-[4-[[(1R)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl]methyl]phenoxy]phenyl]methyl]-6-methoxy-2-methyl-7-isoquinolinol

Synonyms:  (–)-Daurisoline|(R,R)-Daurisoline

Molecular weight: 610.7

CAS: 70553-76-3

Purity: ≥98%

Formulation: A solid

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