An antitumor antibiotic that induces apoptosis in mature monocytic U937 and myelocytic HL-60 acute myeloid leukemia cells at 0.2-1 μM; triggers a ROS-dependent sphingomyelin-ceramide pathway that activates the MEKK1-SEK1-JNK

Daunorubicin (hydrochloride) – 10 mg

Brand:
Cayman
CAS:
23541-50-6
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Daunorubicin is an antitumor antibiotic.{22542} At 0.2-1μM, daunorubicin induces apoptosis in mature monocytic U937 and myelocytic HL-60 acute myeloid leukemia (AML) cells. However, immature AML cells (CD 34+-KG1a, -KG1, or -HEL cells) appear resistant to apoptosis at similar concentrations.{22542} In mature AML cells, daunorubicin has been shown to trigger a reactive oxygen species-dependent sphingomyelin-ceramide pathway that activates the MEKK1-SEK1-JNK cascade leading to enhanced DNA binding activity of the transcription factor AP-1.{22542,5396}  

 

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Description

An antitumor antibiotic that induces apoptosis in mature monocytic U937 and myelocytic HL-60 acute myeloid leukemia cells at 0.2-1 μM; triggers a ROS-dependent sphingomyelin-ceramide pathway that activates the MEKK1-SEK1-JNK

Formal name: 8S-acetyl-10S-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione, monohydrochloride

Synonyms:  NDC 0082-4155|Ondena|RP 13057

Molecular weight: 564

CAS: 23541-50-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling||Research Area|Cancer|Transcription Factors

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