An HIV-1 protease inhibitor; active against HIV-1LAI in MT-2 cells (IC50 = 3 nM) (CC50 = 74.4 μM); active against wild-type and multidrug-resistant clinical isolates of HIV-1 in PHA-PBMCs (IC50s = 3 and 3-29 nM

Darunavir (ethanolate) – 10 mg

Brand:
Cayman
CAS:
635728-49-3
Storage:
-20
UN-No:
Non-Hazardous - /

Darunavir is an HIV-1 protease inhibitor.{26076} It is active against HIV-1LAI in MT-2 cells (IC50 = 3 nM) with a cytotoxic concentration (CC50) of 74.4 μM. Darunavir is also active against wild-type and multidrug-resistant clinical isolates of HIV-1 in phytohemagglutinin-activated peripheral blood mononuclear cells (PHA-PBMCs; IC50s = 3 and 3-29 nM, respectively). It inhibits cell-free diffusion and cell-to-cell spread of HIV-1 in Jurkat cell populations (IC50s = 2.5 and 2.8 nM, respectively).{26075} Formulations containing darunavir have been used in combination therapy for the treatment of HIV.  

 

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SKU: 31083 - 10 mg Category:

Description

An HIV-1 protease inhibitor; active against HIV-1LAI in MT-2 cells (IC50 = 3 nM) (CC50 = 74.4 μM); active against wild-type and multidrug-resistant clinical isolates of HIV-1 in PHA-PBMCs (IC50s = 3 and 3-29 nM, respectively); inhibits cell-free diffusion and cell-to-cell spread of HIV-1 in Jurkat cell populations (IC50s = 2.5 and 2.8 nM, respectively)

Formal name: N-[(1S,2R)-3-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]-carbamic acid (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl ester, ethanolate

Synonyms:  TMC114

Molecular weight: 593.7

CAS: 635728-49-3

Purity: ≥95%

Formulation: A crystalline solid

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