An HIV-1 protease inhibitor; active against HIV-1LAI in MT-2 cells (IC50 = 3 nM) (CC50 = 74.4 μM); active against wild-type and multidrug-resistant clinical isolates of HIV-1 in PHA-PBMCs (IC50s = 3 and 3-29 nM

Darunavir – 1 mg

Brand:
Cayman
CAS:
206361-99-1
Storage:
-20
UN-No:
Non-Hazardous - /

Darunavir is an HIV-1 protease inhibitor.{26076} It is active against HIV-1LAI in MT-2 cells (IC50 = 3 nM) with a cytotoxic concentration (CC50) of 74.4 μM. Darunavir is also active against wild-type and multidrug-resistant clinical isolates of HIV-1 in phytohemagglutinin-activated peripheral blood mononuclear cells (PHA-PBMCs; IC50s = 3 and 3-29 nM, respectively). It inhibits cell-free diffusion and cell-to-cell spread of HIV-1 in Jurkat cell populations (IC50s = 2.5 and 2.8 nM, respectively).{26075} Formulations containing darunavir have been used in combination therapy for the treatment of HIV.  

 

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Description

An HIV-1 protease inhibitor; active against HIV-1LAI in MT-2 cells (IC50 = 3 nM) (CC50 = 74.4 μM); active against wild-type and multidrug-resistant clinical isolates of HIV-1 in PHA-PBMCs (IC50s = 3 and 3-29 nM, respectively); inhibits cell-free diffusion and cell-to-cell spread of HIV-1 in Jurkat cell populations (IC50s = 2.5 and 2.8 nM, respectively)

Formal name: N-[(1S,2R)-3-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]-carbamic acid, (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl ester

Synonyms:  TMC114

Molecular weight: 547.7

CAS: 206361-99-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals|Protease Inhibitors||Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS

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