A lipopeptide antibiotic effective against resistant Gram-positive bacteria (MIC90s range from 0.25-16 mg/L); alters bacterial plasma membrane potential and redirects the binding of proteins essential for cell division and cell wall synthesis

Daptomycin – 5 mg

Brand:
Cayman
CAS:
103060-53-3
Storage:
-20
UN-No:
Non-Hazardous - /

Daptomycin is a naturally occurring cyclic lipopeptide produced by the soil saprotroph S. roseosporus that is effective against resistant Gram-positive bacteria (MIC90s range from 0.25-16 mg/L).{25676,25675} It binds to bacterial plasma membranes to disrupt multiple aspects of function, including altering membrane potential and redirecting proteins essential for cell division and cell wall synthesis.{25675,25674}  

 

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Description

A lipopeptide antibiotic effective against resistant Gram-positive bacteria (MIC90s range from 0.25-16 mg/L); alters bacterial plasma membrane potential and redirects the binding of proteins essential for cell division and cell wall synthesis

Formal name: 2,2′-((3S,6S,9R,15S,18R,21S,24S,30S,31R)-30-((S)-2-((R)-4-amino-2-((S)-2-decanamido-3-(1H-indol-3-yl)propanamido)-4-oxobutanamido)-3-carboxypropanamido)-3-(2-(2-aminophenyl)-2-oxoethyl)-24-(3-aminopropyl)-6-((R)-1-carboxypropan-2-yl)-9-(hydroxymethyl)-18,31-dimethyl-2,5,8,11,14,17,20,23,26,29-decaoxo-1-oxa-4,7,10,13,16,19,22,25,28-nonaazacyclohentriacontane-15,21-diyl)diacetic acid

Synonyms:  LY146032

Molecular weight: 1,620.70

CAS: 103060-53-3

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Peptides||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases

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