A diarylpyrimidine derivative of the potent NNRTI efavirenz; inhibits HIV-1 reverse transcriptase (IC50= 24 nM: impedes the late stages of HIV-1 infection by interfering with HIV-1 Gag-Pol polyprotein processing

Dapivirine – 5 mg

Brand:
Cayman
CAS:
244767-67-7
Storage:
-20
UN-No:
Non-Hazardous - /

Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are highly specific and potent allosteric inhibitors of HIV-1 reverse transcriptase. Dapivirine, a diarylpyrimidine derivative of the potent NNRTI efavirenz (Item No. 14412), inhibits HIV-1 reverse transcriptase with an IC50 value of 24 nM in vitro.{29624} It impedes the late stages of HIV-1 infection by interfering with HIV-1 Gag-Pol polyprotein processing.{22818}  

 

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Description

A diarylpyrimidine derivative of the potent NNRTI efavirenz; inhibits HIV-1 reverse transcriptase (IC50= 24 nM: impedes the late stages of HIV-1 infection by interfering with HIV-1 Gag-Pol polyprotein processing,

Formal name: 4-[[4-[(2,4,6-trimethylphenyl)amino]-2-pyrimidinyl]amino]-benzonitrile

Synonyms:  R147681|TMC120

Molecular weight: 329.4

CAS: 244767-67-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals|Non-nucleoside Reverse Transcriptase Inhibitors (NNRTIs)||Product Type|Biochemicals|Small Molecule Inhibitors|Reverse Transcriptases||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS

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