A coumarin with diverse biological activities; induces aggregation of washed rabbit platelets (EC50 = 17.2 μM); active against RSV in a plaque reduction assay using HEp-2 cells (IC50 = 5.87 μg/ml); halts the cell cycle at the G2/M phase

Daphnoretin – 25 mg

Brand:
Cayman
CAS:
2034-69-7
Storage:
-20
UN-No:
Non-Hazardous - /

Daphnoretin is a coumarin that has been found in W. indica and has diverse biological activities.{48370,48371,48372} It induces aggregation of washed rabbit platelets (EC50 = 17.2 μM), an effect that is reversed by the protein kinase C (PKC) inhibitor staurosporine (Item No. 81590).{48370} Daphnoretin is active against respiratory syncytial virus (RSV) in a plaque reduction assay using HEp-2 cells (IC50 = 5.87 μg/ml).{48371} It halts the cell cycle at the G2/M phase, induces apoptosis, and inhibits proliferation of human osteosarcoma (HOS) cells (IC50 = 3.89 μM).{48372} Daphnoretin also reduces proliferation, invasion, and migration of HCT116 colon cancer cells in a concentration-dependent manner.{48373}  

 

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SKU: 26408 - 25 mg Category:

Description

A coumarin with diverse biological activities; induces aggregation of washed rabbit platelets (EC50 = 17.2 μM); active against RSV in a plaque reduction assay using HEp-2 cells (IC50 = 5.87 μg/ml); halts the cell cycle at the G2/M phase, induces apoptosis, and inhibits proliferation of HOS cells (IC50 = 3.89 μM); reduces proliferation, invasion, and migration of HCT116 colon cancer cells

Formal name: 7-hydroxy-6-methoxy-3-[(2-oxo-2H-1-benzopyran-7-yl)oxy]-2H-1-benzopyran-2-one

Synonyms:  NSC 291852

Molecular weight: 352.3

CAS: 2034-69-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Natural Products|Coumarins||Product Type|Biochemicals|Small Molecule Activators|Kinases||Research Area|Cancer|Cell Cycle|G2/M||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|RSV Infections

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