A phthalimide with diverse biological activities; an EGFR inhibitor that selectively inhibits the EGFR intracellular kinase domain over v-Abl

DAPH – 1 mg

Brand:
Cayman
CAS:
145915-58-8
Storage:
-20
UN-No:
Non-Hazardous - /

DAPH is a phthalimide with diverse biological activities.{47738,47739,47740,47741} It is an EGFR inhibitor that selectively inhibits the EGFR intracellular kinase domain over v-Abl, c-Src, PKCα, PKCβ1, PKCβ2, and PKCγ (IC50s = 0.3, >50, 16, 6, 30, 4.8, and 30 μM, respectively) and a panel of 11 other kinases.{47738} It also inhibits EGFR autophosphorylation in A431 human epidermoid carcinoma cell membranes and intact cells (IC50s = 1 and 17205) in isolated rat endothelium-denuded aortic rings in a concentration-dependent manner.{47739} It inhibits aggregation of amyloid-β (1-42) (Aβ42) peptide (Item No. 20574), disaggregates preformed Aβ42 fibrils, and inhibits calcium influx into mouse CATH.a neuronal cells when used at a concentration of 10 μM.{47740} DAPH also inhibits aggregation of a Sup35 yeast prion protein fragment that contains its N-terminal and highly charged middle domains (IC50 = 0.58 μM).{47741}  

 

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SKU: 29196 - 1 mg Category:

Description

A phthalimide with diverse biological activities; an EGFR inhibitor that selectively inhibits the EGFR intracellular kinase domain over v-Abl, c-Src, PKCα, PKCβ1, PKCβ2, and PKCγ (IC50s = 0.3, >50, 16, 6, 30, 4.8, and 30 μM, respectively) and a panel of 11 other kinases; inhibits EGFR autophosphorylation in A431 human epidermoid carcinoma cell membrane preparations and intact cells (IC50s = 1 and 50 = 0.58 μM)

Formal name: 5,6-bis(phenylamino)-1H-isoindole-1,3(2H)-dione

Synonyms:  4,5-Dianilinophthalimide|CGP 52411

Molecular weight: 329.4

CAS: 145915-58-8

Purity: ≥98%

Formulation: A crystalline solid

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