A metabolite of dapagliflozin; 2

Dapagliflozin-3-O-β-D-Glucuronide – 1 mg

Brand:
Cayman
CAS:
1351438-75-9
Storage:
-20
UN-No:
Non-Hazardous - /

Dapagliflozin-3-O-β-D-glucuronide is a metabolite of dapagliflozin (Item No. 11574). Dapagliflozin is a first generation selective sodium glucose cotransporter (SGLT) 2 inhibitor that blocks glucose transport.{20896} Dapagliflozin is metabolized by uridine diphosphate glucuronosyltransferase (UGT) 1A9 to dapagliflozin-3-O-β-D-glucuronide, which is 2,600-fold less potent than the parent compound with regard to SGLT2 inhibition.{38069}  

 

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Description

A metabolite of dapagliflozin; 2,600-fold less potent than parent drug with regard to SGLT2 inhibition,

Formal name: (1S)-1,5-anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-3-O-β-D-glucopyranuronosyl-D-glucitol

Synonyms: 

Molecular weight: 585

CAS: 1351438-75-9

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Toxicology|Drug Metabolism|Drug Metabolites

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