An inhibitor of sarcoplasmic reticulum calcium release (IC50 = 0.3 µM); binds to sarcoplasmic reticulum vesicles isolated from normal and MHS pigs (Kds = 0.3 and 0.09 µM

Dantrolene (sodium salt) – 1 g

Brand:
Cayman
CAS:
14663-23-1
Storage:
-20
UN-No:
Non-Hazardous - /

Dantrolene is an inhibitor of calcium release from the sarcoplasmic reticulum (IC50 = 0.3 µM).{53099} It binds to sarcoplasmic reticulum vesicles isolated from normal and malignant hyperthermia-susceptible (MHS) pigs with Kd values of 0.3 and 0.09 µM, respectively. Dantrolene reduces spontaneous calcium wave frequency and amplitude in the presence of calmodulin in isolated mouse cardiomyocytes with IC50 values of 0.42 and 0.19 µM, respectively.{53100} It reduces the magnitude of electrically stimulated twitch tensions in isolated rat extensor digitorum longus and soleus muscles (IC50 = 3 µg/ml) and MHS pigs (ED50 = 0.85 mg/kg).{53101,53102} Formulations containing dantrolene have been used in the treatment of malignant hyperthermia.  

 

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Description

An inhibitor of sarcoplasmic reticulum calcium release (IC50 = 0.3 µM); binds to sarcoplasmic reticulum vesicles isolated from normal and MHS pigs (Kds = 0.3 and 0.09 µM, respectively); reduces spontaneous calcium wave frequency and amplitude in the presence of calmodulin in isolated mouse cardiomyocytes (IC50s = 0.42 and 0.19 µM, respectively); reduces the magnitude of electrically stimulated twitch tensions in isolated rat extensor digitorum longus and soleus muscles (IC50 = 3 µg/ml) and MHS pigs (ED50 = 0.85 mg/kg)

Formal name: 1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidinedione, monosodium salt

Synonyms: 

Molecular weight: 336.2

CAS: 14663-23-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Cardiovascular System|Heart||Research Area|Cell Biology|Cell Signaling|Calcium Mobilization||Research Area|Neuroscience

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