A salvianolic acid with diverse biological activities; reduces expression of p62

Danshensu (sodium salt) – 50 mg

Brand:
Cayman
CAS:
67920-52-9
Storage:
-20
UN-No:
Non-Hazardous - /

Danshensu is a salvianolic acid and the major component of S. miltiorrhiza (Danshen) and has diverse biological activities.{47430,47431,47432,47433} It reduces expression of the autophagy-associated proteins p62, LC3-II, and Beclin-1 and the apoptosis-related proteins Bax and caspase-3, prevents cardiomyocyte damage, and increases heart rate, coronary flow (CF), and left ventricular developed pressure (LVDP) in an isolated rat heart model of ischemia and reperfusion injury.{47430} Danshensu (60 mg/kg per day) reduces infarct size and improves left ventricular function in a rat model of myocardial infarction.{47431} It enhances radiation-induced tumor cell death in a Lewis lung carcinoma mouse xenograft model.{47432} Danshensu also decreases infarct volume, neuronal apoptosis, production of TNF-α, IL-1β, and IL-6, and superoxide dismutase (SOD) and glutathione peroxidase (GPx) activity in a rat model of cerebral ischemia and reperfusion injury.{47433}  

 

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Description

A salvianolic acid with diverse biological activities; reduces expression of p62, LC3-II, Beclin-1, Bax, and caspase-3, prevents cardiomyocyte damage, and increases heart rate, CF, and LVDP in an isolated rat heart model of ischemia and reperfusion injury; reduces infarct size and improves left ventricular function in a rat model of myocardial infarction at 60 mg/kg per day; enhances radiation-induced tumor cell death in a Lewis lung carcinoma mouse xenograft model; decreases infarct volume, neuronal apoptosis, production of TNF-α, IL-1β, and IL-6, and SOD and GPx activity in a rat model of cerebral ischemia and reperfusion injury

Formal name: α,3,4-trihydroxy-benzenepropanoic acid, monosodium salt

Synonyms: 

Molecular weight: 220.2

CAS: 67920-52-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products||Research Area|Cancer||Research Area|Cardiovascular System|Cardiovascular Diseases|Myocardial Infarction||Research Area|Cardiovascular System|Cardiovascular Diseases|Stroke||Research Area|Cardiovascular System|Heart|Arrhythmia||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Immunology & Inflammation||Research Area|Neuroscience|Neuroprotection|Ischemia||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Gluthathione Peroxidase||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Superoxide Dismutase

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