A semisynthetic glycopeptide antibiotic; inhibits the growth of Gram-positive bacteria in vitro

Dalbavancin – 25 mg

Brand:
Cayman
CAS:
171500-79-1
Storage:
-20
UN-No:
Non-Hazardous - /

Dalbavancin is a semisynthetic glycopeptide antibiotic.{45081} It inhibits the growth of Gram-positive bacteria in vitro, including S. pneumoniae, S. pyogenes, vancomycin-sensitive Enterococcus species, and various methicillin-resistant staphylococci (MIC50s = 0.03, ≤0.002, 0.13, and 0.03-0.13 mg/L, respectively). Dalbavancin increases survival in mouse models of infection with S. aureus and S. pneumoniae (ED50s = 0.08 and 0.56 mg/kg, respectively). Formulations containing dalbavancin have been used in the treatment of bacterial skin infections caused by Gram-positive bacteria.  

 

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Description

A semisynthetic glycopeptide antibiotic; inhibits the growth of Gram-positive bacteria in vitro, including S. pneumoniae, S. pyogenes, vancomycin-sensitive Enterococcus species, and various methicillin-resistant staphylococci (MIC50s = 0.03, ≤0.002, 0.13, and 0.03-0.13 mg/L, respectively); increases survival in mouse models of infection with S. aureus and S. pneumoniae (ED50s = 0.08 and 0.56 mg/kg, respectively)

Formal name: 5,31-dichloro-38-de(methoxycarbonyl)-7-demethyl-19-deoxy-56-O-[2-deoxy-2-[(10-methyl-1-oxoundecyl)amino]-β-D-glucopyranuronosyl]-38-[[[3-(dimethylamino)propyl]amino]carbonyl]-42-O-α-D-mannopyranosyl-N15-methyl-ristomycin A aglycone

Synonyms:  BI 397|MDL 63397

Molecular weight: 1,816.70

CAS: 171500-79-1

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Antibiotics|Glycopeptides & Lipoglycopeptides||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases|MRSA||Research Area|Infectious Disease|Bacterial Diseases|Pneumonia

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