An isoflavone; binds to ERβ (Ki = 2.8 µM) but not ERα up to 1 mM; estrogenic in vitro

Daidzein – 1 g

Brand:
Cayman
CAS:
486-66-8
Storage:
-20
UN-No:
Non-Hazardous - /

Daidzein is an isoflavone phytoestrogenic compound that has been found in soybeans and other legumes.{42157} It binds to estrogen receptor β (ERβ; Ki = 2.8 µM) but not ERα at concentrations up to 1 mM.{42156} It is estrogenic in vitro, increasing gene transcription mediated by the estrogen response element (ERE) in a reporter assay in an ERβ-dependent manner (EC50 = 2.8 µM for MCF-7 cells expressing ERβ).{42157} Daidzein is an inhibitor of carbonic anhydrase (CA) that is selective for carbonic CAVII and CAXII (Kis = 4.2 and 56 nM, respectively) over CAI, II, and IV (Kis = >10,000, >10,000, and 718.7 nM, respectively).{42158} It reduces tumor growth in a PC3 prostate cancer mouse orthotopic model when administered at a dose of 50 mg/kg per day and potentiates the effects of radiation therapy.{42159}  

 

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SKU: 10005166 - 1 g Category:

Description

An isoflavone; binds to ERβ (Ki = 2.8 µM) but not ERα up to 1 mM; estrogenic in vitro, increasing ERE-mediated gene transcription via ERβ (EC50 = 2.8 µM); an inhibitor of CAVII and CAXII (Kis = 4.2 and 56 nM, respectively) and selective for them over CAI, II, and IV (Kis = >10,000, >10,000, and 718.7 nM, respectively); reduces tumor growth in a PC3 prostate cancer mouse orthtopic model at 50 mg/kg per day

Formal name: 7-hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one

Synonyms: 

Molecular weight: 254.2

CAS: 486-66-8

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Flavonoids||Product Type|Biochemicals|Natural Products|Phytosterols||Product Type|Biochemicals|Receptor Pharmacology||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Estrogens & Progestins

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