A peptide agonist of δ-opioid receptors (Ki = 2.06 nM in a radioligand binding assay); selective for δ-opioid over κ-opioid receptors (Ki = 16

DADLE – 1 mg

Brand:
Cayman
CAS:
63631-40-3
Storage:
-20
UN-No:
Non-Hazardous - /

DADLE is a peptide agonist of δ-opioid receptors (Ki = 2.06 nM in a radioligand binding assay).{37712} It is selective for δ-opioid over κ-opioid receptors (Ki = 16,000 nM) but also agonizes μ-opioid receptors (Ki = 13.8 nM). DADLE inhibits electrically induced contractions in guinea pig myenteric plexus and mouse and rat vas deferens (IC50s = 8.9, 0.73, and 134 nM, respectively). It induces analgesia in the tail-flick and hot plate tests in mice (ED50s = 0.03 and 0.027 nmol per animal, i.c.v.).{52196} DADLE (2.5 mg/kg) decreases infarct volume in a rat model of cerebral ischemia-reperfusion injury induced by middle cerebral artery occlusion (MCAO).{52197}  

 

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Description

A peptide agonist of δ-opioid receptors (Ki = 2.06 nM in a radioligand binding assay); selective for δ-opioid over κ-opioid receptors (Ki = 16,000 nM) but also agonizes of μ-opioid receptors (Ki = 13.8 nM); inhibits electrically induced contractions in guinea pig myenteric plexus and mouse and rat vas deferens (IC50s = 8.9, 0.73, and 134 nM, respectively); induces analgesia in the tail-flick and hot plate tests in mice (ED50s = 0.03 and 0.027 nmol per animal, i.c.v.); decreases infarct volume in a rat model of MCAO-induced cerebral ischemia-reperfusion injury at 2.5 mg/kg

Formal name: L-tyrosyl-D-alanylglycyl-L-phenylalanyl-D-leucine

Synonyms:  [D-Ala2, D-Leu5]-Enkephalin

Molecular weight: 569.7

CAS: 63631-40-3

Purity: ≥98%

Formulation: A crystalline solid

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