Description
An NS5A inhibitor (Kds = 8 and 210 nM for the NS5A33-202 and NS5A26-202 residues of HCV genotype 1b, respectively); potently inhibits HCV replication in multiple HCV replicon genotypes (EC50s = 9-146 pM) with the highest potency in genotypes 1b and 4a (EC50s = 9 and 12 pM, respectively); disrupts NS5A subcellular localization when used at a concentration of 1 nM; inhibits HCV RNA synthesis and virion assembly and secretion when used at a concentration of 1 nM; inhibits OAT1B1 and OAT1B3 (IC50s = 1.5 and 3.27 µM, respectively)
Formal name: N,N’-[[1,1′-biphenyl]-4,4′-diylbis[1H-imidazole-5,2-diyl-(2S)-2,1-pyrrolidinediyl[(1S)-1-(1-methylethyl)-2-oxo-2,1-ethanediyl]]]bis-carbamic acid, C,C’-dimethyl ester
Synonyms: BMS 790052
Molecular weight: 738.9
CAS: 1009119-64-5
Purity: ≥95%
Formulation: A solid
Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Small Molecule Inhibitors||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|Hepatitis
