A major active metabolite of dabigatran; formed via UGT2B15-mediated metabolism of dabigatran; increases aPTT in isolated human platelet-poor plasma equipotently to dabigatran

Dabigatran Acyl-β-D-Glucuronide – 1 mg

Brand:
Cayman
CAS:
1015167-40-4
Storage:
-20
UN-No:
Non-Hazardous - /

Dabigatran acyl-β-D-glucuronide is a major active metabolite of the thrombin inhibitor dabigatran (Item No. 17133). The prodrug of dabigatran, dabigatran etexilate (Item No. 17131), is hydrolyzed by plasma esterases to form dabigatran, which is metabolized primarily by the UDP-glucuronosyltransferase (UGT) isoform UGT2B15 to form dabigatran acyl-β-D-glucuronide.{28064,43581} Dabigatran acyl-β-D-glucuronide increases activated partial thromboplastin time (aPTT) in isolated human platelet-poor plasma equipotently to dabigatran.{43581}  

 

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SKU: 26655 - 1 mg Category:

Description

A major active metabolite of dabigatran; formed via UGT2B15-mediated metabolism of dabigatran; increases aPTT in isolated human platelet-poor plasma equipotently to dabigatran

Formal name: N-[[2-[[[4-(aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-β-alanine, β-D-glucopyranuronosyl ester

Synonyms:  β-1-O-Acylglucuronide

Molecular weight: 647.6

CAS: 1015167-40-4

Purity: ≥90%

Formulation: A solid

Product Type|Biochemicals|Small Molecule Inhibitors|Blood Coagulation Factors||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Cardiovascular System|Blood|Coagulation & Hemostasis||Research Area|Cell Biology|Proteolysis|Cytosolic & Secreted Proteases||Research Area|Toxicology|Drug Metabolism|Drug Metabolites

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