A cyclitol with diverse biological activities; decreases NF-κB gene expression and induces DNA fragmentation and apoptosis in MCF-7 breast cancer cells; induces endothelium- and nitric oxide-dependent vasodilation in isolated mouse mesenteric arteries; reduces systolic blood pressure in mice at 10 mg/kg; enhances creatine clearance

D-Pinitol – 1 g

Brand:
Cayman
CAS:
10284-63-6
Storage:
4
UN-No:
Non-Hazardous - /

D-Pinitol is a cyclitol that has been found in several plants, including soybean and carob, and has diverse biological activities.{47256,47257,47258,47259} It decreases NF-κB gene expression and induces DNA fragmentation and apoptosis in MCF-7 breast cancer cells.{47256} D-Pinitol induces endothelium- and nitric oxide-dependent vasodilation in isolated mouse mesenteric arteries.{47257} In vivo, D-pinitol (10 mg/kg, i.p.) reduces systolic blood pressure in mice. D-Pinitol (50 mg/kg) enhances creatine clearance, reduces tubulointerstitial fibrosis, and increases levels of the cytosolic antioxidant enzymes superoxide dismutase I (SOD1) and NAD(P)H:quinone oxidoreductase (NQO1) in a mouse model of cyclosporin A-induced nephropathy.{47258} It also decreases plasma glucose levels in a mouse model of diabetes induced by streptozotocin (Item No. 13104).{47259}  

 

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SKU: 26815 - 1 g Category:

Description

A cyclitol with diverse biological activities; decreases NF-κB gene expression and induces DNA fragmentation and apoptosis in MCF-7 breast cancer cells; induces endothelium- and nitric oxide-dependent vasodilation in isolated mouse mesenteric arteries; reduces systolic blood pressure in mice at 10 mg/kg; enhances creatine clearance, reduces tubulointerstitial fibrosis, and increases levels of the cytosolic antioxidant enzymes SOD1 and NQO1 in a mouse model of cyclosporin A-induced nephropathy at 50 mg/kg; decreases plasma glucose levels in a mouse model of streptozotocin-induced diabetes

Formal name: 3-O-methyl-D-chiro-inositol

Synonyms:  3-O-methyl-Chiroinositol

Molecular weight: 194.2

CAS: 10284-63-6

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|DNA Damage and Repair||Research Area|Cardiovascular System|Vasculature|Vasodilation||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Superoxide Dismutase

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