Ins(1

D-myo-Inositol-1,4,6-triphosphate (sodium salt) – 500 µg

Brand:
Cayman
CAS:
157380-18-2
Storage:
-20
UN-No:
Non-Hazardous - /

D-myo-Inositol-1,4,6-phosphate (Ins(1,4,6)-P3) is a member of the inositol phosphate (InsP) family that play critical roles as small, soluble second messengers in the transmission of cellular signals.{8672,8344} The most studied InsP, Ins(1,4,5)-P3, is a second messenger produced in cells by phospholipase C (PLC)-mediated hydrolysis of phosphatidylinositol-4,5-biphosphate.{2429,5714} Binding of Ins(1,4,5)-P3 to its receptor on the endoplasmic reticulum results in opening of the calcium channels and an increase in intracellular calcium.{5714,4096} Ins(1,4,6)-P3 (tested as the meso compound) is 9-fold less potent than Ins(1,4,5)-P3 at initiating Ca2+ release when injected into Xenopus oocytes.{13725}  

 

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SKU: 10008427 - 500 µg Category:

Description

Ins(1,4,6)-P3 is a member of the InsP family that play critical roles as small, soluble second messengers in the transmission of cellular signals.{8672,8344} The most studied InsP, Ins(1,4,5)-P3, is a second messenger produced in cells by PLC-mediated hydrolysis of phosphatidylinositol-4,5-biphosphate.{2429,5714} Binding of Ins(1,4,5)-P3 to its receptor on the endoplasmic reticulum results in opening of the calcium channels and an increase in intracellular calcium.{5714,4096} Ins(1,4,6)-P3 (tested as the meso compound) is 9-fold less potent than Ins(1,4,5)-P3 at initiating Ca2+ release when injected into Xenopus oocytes.{13725}

Formal name: D-myo-Insitol-1,4,6-tris(dihydrogen phosphate), trisodium salt

Synonyms:  1,4,6-IP3|Ins(1,4,6)-P3

Molecular weight: 486

CAS: 157380-18-2

Purity: ≥98%

Formulation: A lyophilized powder

Product Type|Biochemicals|Ion Channel Modulation|Activators||Research Area|Cell Biology|Cell Signaling||Research Area|Cell Biology|Inositol Phosphates

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