Description
Ins(1,4,5,6)-P4 is one of several different inositol oligophosphate isomers implicated in signal transduction. Production of Ins(1,4,5,6)-P4 by intestinal epithelial cells increases approximately 2-14 fold, depending on the strain and incubation time, following infection with Salmonella.{13729} Ins(1,4,5,6)-P4 antagonizes epidermal growth factor (EGF) signalling through the phosphatidylinositol 3-kinase pathway.{13729} Ins(1,4,5,6)-P4 (tested as the D/L racemic mixture) is ~1,000-fold less potent than Ins(1,4,5)-P3 at initiating Ca2+ release when injected into Xenopus oocytes.{13725}
Formal name: D-myo-inositol-1,4,5,6-tetra(hydrogen phosphate), tetrasodium salt
Synonyms: 1,4,5,6-IP4|Ins(1,4,5,6)-P4
Molecular weight: 588
CAS: 157542-47-7
Purity: ≥98%
Formulation: A lyophilized powder
Product Type|Biochemicals||Research Area|Cell Biology|Cell Signaling||Research Area|Cell Biology|Inositol Phosphates||Research Area|Lipid Biochemistry|Glycerophospholipids|Phosphatidyl Inositol Kinases & Phosphatases
