An antagonist of HCA3/GPR109B (EC50 = 2.61 µM in a luciferase reporter assay) and a metabolite of D-tryptophan; increases levels of intracellular calcium

D-Kynurenine – 250 mg

Brand:
Cayman
CAS:
13441-51-5
Storage:
-20
UN-No:
Non-Hazardous - /

D-Kynurenine is an antagonist of hydroxycarboxylic acid receptor 3 HCA3/GPR109B (EC50 = 2.61 µM in a luciferase reporter assay) and a metabolite of D-tryptophan.{46426} It increases levels of intracellular calcium and decreases forskolin-stimulated production of cAMP in CHO cells expressing human HCA3/GPR109B when used at concentrations of 10 and 100, or 1,000 µM, respectively. D-Kynurenine (10 µM) increases expression of vimentin and decreases expression of E-cadherin in 95D lung cancer cells.{46427} It has been used as a substrate in fluorometric assays for D-amino acid oxidase activity.{46428,46429}  

 

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SKU: 28254 - 250 mg Category:

Description

An antagonist of HCA3/GPR109B (EC50 = 2.61 µM in a luciferase reporter assay) and a metabolite of D-tryptophan; increases levels of intracellular calcium, and decreases forskolin-stimulated production of cAMP, in CHO cells expressing human HCA3/GPR109B when used at 10 and 100, or 1,000 µM, respectively; increases expression of vimentin and decreases expression of E-cadherin in 95D lung cancer cells at 10 µM; has been used as a substrate in fluorometric assays for D-amino acid oxidase activity

Formal name: αR,2-diamino-γ-oxo-benzenebutanoic acid

Synonyms: 

Molecular weight: 208.2

CAS: 13441-51-5

Purity: ≥98%

Formulation: A crystalline solid

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