A bioactive sphingolipid; agonist of S1P1

D-erythro Lysosphingomyelin (d18:1) – 1 mg

Brand:
Cayman
CAS:
1670-26-4
Storage:
-20
UN-No:
Non-Hazardous - /

D-erythro Lysosphingomyelin is a bioactive sphingolipid.{37413} It is an agonist of sphingosine-1-phosphate receptor 1 (S1P1), S1P2, and S1P3 (EC50s = 167.7, 368.1, and 482.6 nM, respectively, for the human receptors). D-erythro Lysosphingomyelin is also an agonist of the orphan receptor ovarian cancer G protein-coupled receptor 1 (ORG1) that induces calcium accumulation in cells overexpressing OGR1 (EC50 = ~35 nM).{59108} Levels of D-erythro lysosphingomyelin are increased in skin isolated from patients with atopic dermatitis, as well as postmortem brain from patients with Niemann-Pick disease type A, but not type B.{18804,59109}  

 

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SKU: 10007947 - 1 mg Category:

Description

A bioactive sphingolipid; agonist of S1P1, S1P2, and S1P3 (EC50s = 167.7, 368.1, and 482.6 nM, respectively, for the human receptors); agonist of ORG1 that induces calcium accumulation in cells overexpressing OGR1 (EC50 = ~35 nM); levels are increased in skin isolated from patients with atopic dermatitis, as well as postmortem brain from patients with Niemann-Pick disease type A

Formal name: 2-[[[[2S-amino-3R-hydroxy-4E-octadecenyl]oxy]hydroxyphosphinyl]oxy]-N,N,N-trimethyl-ethanaminium

Synonyms:  D-erythro Lyso SM(18:1)|D-erythro Sphingosine-1-Phosphocholine (d18:1)|D-erythro-Sphingophosphorylcholine|Lyso-SM(d18:1)|Lysosphingomyelin (d18:1)

Molecular weight: 464.6

CAS: 1670-26-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Sphingolipids||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Endocrinology & Metabolism|Inborn Errors of Metabolism||Research Area|Lipid Biochemistry|Sphingolipids||Research Area|Neuroscience

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