A NMDAR partial agonist selective for the glycine (Ki = 2.33 μM) over glutamate (Ki = >100 μM) binding site; improves memory retention in CD-1 mice (10-30 mg/kg); improves memory retention in ‘senescence-accelerated’ mice (20-40 mg/kg); inhibits enzymes essential to bacterial cell wall formation

D-Cycloserine – 1 g

Brand:
Cayman
CAS:
68-41-7
Storage:
-20
UN-No:
Non-Hazardous - /

D-Cycloserine is an NMDA receptor (NMDAR) partial agonist with antibiotic activity. It selectively binds to the glycine binding site (Ki = 2.33 μM) over the glutamate binding site (Ki = >100 μM).{39065} D-Cycloserine modulates memory in a T-maze footshock test in CD-1 mice with optimal memory retention at doses of 10-30 mg/kg.{39066} Administration of D-cycloserine (20-40 mg/kg) improves memory retention in ‘senescence-accelerated’ mice which exhibit impaired learning and memory. D-Cycloserine inhibits L-alanine racemase and D-alanine:D-alanine ligase, enzymes essential to peptidoglycan synthesis and bacterial cell wall formation.{39068} Formulations containing D-cycloserine have been used as second-line agents to treat drug resistant tuberculosis.{39069}  

 

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Description

A NMDAR partial agonist selective for the glycine (Ki = 2.33 μM) over glutamate (Ki = >100 μM) binding site; improves memory retention in CD-1 mice (10-30 mg/kg); improves memory retention in ‘senescence-accelerated’ mice (20-40 mg/kg); inhibits enzymes essential to bacterial cell wall formation

Formal name: 4R-amino-3-isoxazolidinone

Synonyms:  (+)-Cycloserine|(R)-Cycloserine|NSC 154851|NSC 76029|α-Cycloserine

Molecular weight: 102.1

CAS: 68-41-7

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Ion Channel Modulation|Activators||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases|Tuberculosis||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory

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