Description
An inhibitor of tubulin polymerization (IC50 = 0.53 µM); arrests the cell cycle at the G2/M transition (IC50 = 92 nM); preferentially cytotoxic to cycling cells; has antiproliferative activity in various cancer cell lines (IC50s = 24-144 nM) and in cell lines resistant to other tubulin inhibitors (IC50s = 20-77 nM); reduces tumor growth in a mouse xenograft model of human amelanoic melanoma at doses of 200 and 400 mg/kg,
Formal name: (5-methoxy-1H-indol-2-yl)phenyl-methanone
Synonyms:
Molecular weight: 251.3
CAS: 74588-78-6
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals||Research Area|Cancer|Cell Cycle|G2/M||Research Area|Cancer|Multidrug Resistance
