A cell-permeant inhibitor of CK1 (IC50 = 200 nM from S. pombe

D 4476 – 1 mg

Brand:
Cayman
CAS:
301836-43-1
Storage:
-20
UN-No:
Non-Hazardous - /

D 4476 is a cell-permeant inhibitor of casein kinase 1 (CK1; IC50 = 200 nM from S. pombe,{17330} 300 nM for CK1δ{17331}). It is a less effective inhibitor of PKD1 (IC50 = 9.1 μM) and p38α MAPK (IC50 = 5.8 μM), and only weakly affects the activities of a panel of kinases tested.{17331} D 4476 blocks CK1-mediated phosphorylation of FOXO1a,{17330} RhoB,{17333} and p53.{17334} As an inhibitor of ALK5, D 4476 prevents Smad3 activation and suppresses TGF-β1-induced gene expression without cytotoxicity in A498 cells.{16928}  

 

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Description

A cell-permeant inhibitor of CK1 (IC50 = 200 nM from S. pombe, 300 nM for CK1δ); only weakly affects the activities of a panel of kinases tested

Formal name: 4-[4-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-(2-pyridinyl)1H-imidazol-2-yl]-benzamide

Synonyms:  Casein Kinase I Inhibitor

Molecular weight: 398.4

CAS: 301836-43-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|CK1||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|Casein Kinase Signaling||Research Area|Cancer|Transcription Factors

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