A selective PI3Kγ inhibitor (IC50 = 1.0 μM in a PI3Kγ-dependent fMLP-induced neutrophil migration assay)

CZC-24832 – 25 mg

Brand:
Cayman
CAS:
1159824-67-5
Storage:
-20
UN-No:
Non-Hazardous - /

CZC-24832 is an inhibitor of PI3K with selectivity for the γ isoform (IC50 = 1.0 μM in a PI3Kγ-dependent fMLP-induced neutrophil migration assay) with limited off target effects in kinome profiling of 154 kinases and 922 other proteins.{32561} This compound demonstrates efficacy in in vitro and in vivo models of inflammation.{32561}  

 

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Description

A selective PI3Kγ inhibitor (IC50 = 1.0 μM in a PI3Kγ-dependent fMLP-induced neutrophil migration assay)

Formal name: 5-(2-amino-8-fluoro[1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-(1,1-dimethylethyl)-3-pyridinesulfonamide

Synonyms: 

Molecular weight: 364.4

CAS: 1159824-67-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|PI3K||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling|PI3K/Akt/mTOR Signaling||Research Area|Immunology & Inflammation|Innate Immunity

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