A natural antitumor inhibitor of cell adhesion to extracellular matrix that potently and selectively inhibits PP2A (IC50 = 29 nM against the catalytic subunit)

Cytostatin (sodium salt) – 250 µg

Brand:
Cayman
CAS:
457070-06-3
Storage:
-20
UN-No:
Non-Hazardous - /

Cytostatin is a natural antitumor inhibitor of cell adhesion to extracellular matrix, blocking adhesion of B16 melanoma cells to laminin and collagen type IV in vitro (IC50s = 1.3 and 1.4 µg/ml, respectively) and B16 cells metastatic activity in mice.{31268,31270} It induces apoptosis of FS3 mouse fibrosarcoma cells (IC50 = 3.1 µg/ml).{31272} Cytostatin potently and selectively inhibits protein phosphatase 2A (PP2A; IC50 = 29 nM against the catalytic subunit), while having no effect against PP1, PP2B, or PP5.{31269,31271}  

 

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Description

A natural antitumor inhibitor of cell adhesion to extracellular matrix that potently and selectively inhibits PP2A (IC50 = 29 nM against the catalytic subunit), while having no effect against PP1, PP2B, or PP5

Formal name: (5S,6S)-5,6-dihydro-6-[(1S,4S,5S,6S,7Z,9Z,11E)-6-hydroxy-1,5-dimethyl-4-(phosphonooxy)-7,9,11-tridecatrien-1-yl]-5-methyl-2H-pyran-2-one, monosodium salt

Synonyms: 

Molecular weight: 450.4

CAS: 457070-06-3

Purity: ≥75%

Formulation: A powder

Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Product Type|Biochemicals|Small Molecule Inhibitors|Phosphatases||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Cancer|Tumor Microenvironment||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|ECM & Adhesion Molecules

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