A naturally occurring agonist for the nuclear receptor Nur77 (IC50 = 0.278 nM); induces apoptosis in cancer cells and retards xenograft tumor growth; induces genes related to gluconeogenesis and decreases atherosclerosis progression in mice fed a high fat/high cholesterol diet

Cytosporone B – 1 mg

Brand:
Cayman
CAS:
321661-62-5
Storage:
-20
UN-No:
Non-Hazardous - /

Cytosporone B is a naturally occurring agonist for the nuclear receptor Nur77 (IC50 = 0.278 nM).{28698} Activation of Nur77 with cytosporone B induces the expression of Nur77-dependent genes, including the gene for Nur77 itself.{28698} Signaling through Nur77 induces apoptosis in cancer cells and retards xenograft tumor growth.{28698} It also induces genes related to gluconeogenesis and decreases atherosclerosis progression in mice fed a high fat and high cholesterol diet.{28698,28695} Cytosporone B is brain penetrant and aggravates early brain injury in rats when given (13 mg/kg intraperitoneally) after experimentally-induced subarachnoid hemorrhage.{28694} Cytosporone B also has antibacterial properties.{28693,28696}  

 

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Description

A naturally occurring agonist for the nuclear receptor Nur77 (IC50 = 0.278 nM); induces apoptosis in cancer cells and retards xenograft tumor growth; induces genes related to gluconeogenesis and decreases atherosclerosis progression in mice fed a high fat/high cholesterol diet

Formal name: 3,5-dihydroxy-2-(1-oxooctyl)-benzeneacetic acid, ethyl ester

Synonyms:  Csn-B|Dothiorelone G

Molecular weight: 322.4

CAS: 321661-62-5

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cardiovascular System|Cardiovascular Diseases|Atherosclerosis||Research Area|Endocrinology & Metabolism|Hormones & Receptors

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