Description
Cytokeratin 8 is a type II epithelial intermediate filament protein.{15723} It is composed of a central rod containing four α-helical domains, which are important for self-assembly, and non-helical head and tail domains at the N- and C-termini, respectively. Cytokeratin 8 is expressed in single-layered epithelial cells and epithelial-derived tumor cells.{59194} It dimerizes with the type I epithelial intermediate filament protein cytokeratin 18 to form a network of filament bundles throughout the cytoplasm.{59195} The tail of cytokeratin 8 binds to plasminogen and mediates invasiveness of cancer cells in vitro.{59196} A null mutation in KRT8, the gene encoding cytokeratin 8, is embryonic lethal in C57BL/6 x 129Sv, but not FVB/N, mice, which develop colorectal hyperplasia.{59197} Substitution mutations in KRT8, corresponding to residues in the head domain of the protein, disrupt filament reorganization following oxidative and non-oxidative stress in vitro and are associated with cryptogenic liver disease.{59194} Intratumoral levels of cytokeratin 8 and -18 are correlated with poor prognosis in patients with squamous cell carcinomas of the oral cavity.{59198} Cayman’s Cytokeratin 8 (C-Term) Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.
Synonyms: CK-8|Cytokeratin-8|Keratin, Type II Cytoskeletal 8|Keratin-8|KRT8
Immunogen: Peptide from the C-terminal region of human cytokeratin 8
Formulation: 100 µl of protein A-affinity purified monoclonal antibody
Isotype: IgG
Applications: IHC and WB
Origin:
Stability: 365 days
Application|Immunohistochemistry||Application|Western Blot||Product Type|Antibodies|Monoclonal Antibodies||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Cardiovascular System|Blood|Serum Proteins||Research Area|Cell Biology|Cytoskeleton & Motor Proteins||Research Area|Oxidative Stress & Reactive Species
