Description
Cytokeratin 14 (CK14) is a type I acidic epithelial intermediate filament protein.{59574} It is composed of a central rod containing four α-helical domains, which are important for self-assembly, and non-helical head and tail domains at the N- and C-termini, respectively.{59575,59576} CK14 is expressed in stratified squamous epithelial cells, keratinocytes, and myoepithelial cells in the basal layer of the epidermis and is an integral component of the epithelial cell cytoskeleton.{59574,59577,59578} It dimerizes with the type II basic epithelial intermediate filament protein CK5 via heptad repeats in the central rod domain to form a network of filament bundles throughout the cytoplasm.{59575,59576} Increased tumor levels of CK14 have been found in patients with squamous cell carcinomas of the bladder, lung, or cervix.{59579} Mutations in the gene encoding CK14 have been found in patients with epidermolysis bullosa simplex (EBS), a disorder characterized by skin blistering.{58059} Cayman’s Cytokeratin 14 (C-Term) Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.
Synonyms: CK14|Cytoskeletal 14|Keratin, Type I Cytoskeletal 14|Keratin-14|KRT14
Immunogen: Peptide from the C-terminal region of human cytokeratin 14
Formulation: 100 µl of protein A-affinity purified monoclonal antibody
Isotype: IgG
Applications: IHC and WB
Origin:
Stability: 365 days
Application|Immunohistochemistry||Application|Western Blot||Product Type|Antibodies|Monoclonal Antibodies||Research Area|Cancer||Research Area|Cell Biology|Cytoskeleton & Motor Proteins
