A radioprotective aminothiol; reduces ionizing radiation-induced death and chromosomal damage in mice in a dose-dependent manner; binds rapidly and temporarily to plasma proteins upon administration and this activity is directly correlated to its radioprotective effects; depletes free cystine from cystinotic fibroblasts in vitro

Cysteamine (hydrochloride) – 25 g

Brand:
Cayman
CAS:
156-57-0
Storage:
-20
UN-No:
Excepted Quantity - 3335 / 9

Cysteamine is a stable aminothiol with radioprotective activities.{41003} It reduces ionizing radiation-induced death and chromosomal damage in mice in a dose-dependent manner.{41003,41004} Cysteamine binds rapidly and temporarily to plasma proteins upon administration and this activity is directly correlated to its radioprotective effects.{41004} In vitro, 0.1 mM cysteamine depletes 90% of free cystine from cystinotic fibroblasts.{41005} Formulations containing cysteamine have been used to treat nephropathic cystinosis and reduce glomerular deterioration in humans.{41006}  

 

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Description

A radioprotective aminothiol; reduces ionizing radiation-induced death and chromosomal damage in mice in a dose-dependent manner; binds rapidly and temporarily to plasma proteins upon administration and this activity is directly correlated to its radioprotective effects; depletes free cystine from cystinotic fibroblasts in vitro ,

Formal name: 2-amino-ethanethiol, monohydrochloride

Synonyms:  CI-9148|β-Mercaptoethylamine

Molecular weight: 113.6

CAS: 156-57-0

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cancer

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