CysLT2 Receptor (C-Term) Polyclonal Antibody – 1 ea

Brand:
Cayman
Storage:

Immunogen: Synthetic peptide from the C-terminal region of human CysLT2 Receptor • Host: Rabbit • Cross Reactivity: (+) CysLT1 • Cross Reactivity: (+) Human; (-) Rat • Application(s): ELISA, FC, IHC, and WB • The CysLT2 receptor binds LTD4, LTC4, and LTE4 playing a major role in asthma by facillitating airway and pulmonary vascular smooth muscle contraction, increased vascular permeability, and stimulating mucus secretion. The mRNA for the human CysLT2 receptor is expressed in lung macrophages, airway smooth muscle, cardiac Purkinje cells, adrenal medulla cells, peripheral blood leukocytes, spleen, placenta, and brain.  

 

SKU: 120550- 1 ea Category:

Description

The cysteinyl leukotrienes (cysLTs; LTC4, LTD4, and LTE4) contract airway and pulmonary vascular smooth muscle, increase vascular permeability, and stimulate mucus secretion, thereby playing a major role in asthma.{3956,2069,3483,4157} LTC4, LTD4, and LTE4 mediate their actions via at least two receptors designated CysLT1 and CysLT2.{3956} Cloning of the human CysLT2 receptor reveals it is a 346 amino acid protein with 38% homology to the CysLT1 receptor.{8519,7174} The rank order of binding for leukotrienes to the cloned receptor, as determined using a radioligand binding assay, is LTC4 = LTD4 >> LTE4.{8519} The mRNA for the human CysLT2 receptor is expressed in lung macrophages, airway smooth muscle, cardiac Purkinje cells, adrenal medulla cells, peripheral blood leukocytes, spleen, placenta, and brain.{8519,9059}


Synonyms: Cysteinyl-Leukotriene Receptor 2

Immunogen: Synthetic peptide from the C-terminal region of human CysLT2 Receptor

Formulation: Peptide affinity-purified polyclonal antibody

Isotype:

Applications: ELISA, FC, IHC, and WB

Origin: Animal/Rabbit

Stability: 365 days


Application|ELISA||Application|Flow Cytometry||Application|Immunohistochemistry||Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Cardiovascular System|Vasculature|Smooth Muscle Cells||Research Area|Lipid Biochemistry|Lipoxygenase Pathways