An anilinopyrimidine fungicide; inhibits the biosynthesis of methionine in phytopathogenic fungi; inhibits mycelial cell growth of B. cinerea

Cyprodinil – 100 mg

Brand:
Cayman
CAS:
121552-61-2
Storage:
-20
UN-No:
De Minimis - 3077 / 9

Cyprodinil is an anilinopyrimidine broad-spectrum fungicide that inhibits the biosynthesis of methionine in phytopathogenic fungi.{37609} It inhibits mycelial cell growth of B. cinerea, P. herpotrichoides, and H. oryzae on amino acid-free media (IC50s = 0.44, 4.8, and 0.03 µM, respectively), an effect that is reversed by addition of methionine or homocysteine. In an MDA-kb2 assay, cyprodinil acts as an androgen receptor (AR) agonist (EC20 = 1.91 µM) in the absence of the AR agonist DHT and inhibits the androgenic effect of DHT (IC20 = 15.1 µM).{42005} It is cytotoxic in a yeast antiandrogen screen (YAS; EC20 = 27.8 µM) but not in an MDA-kb2 assay (EC20 = >50 µM). Cyprodinil increases proliferation of estrogen receptor-expressing BG-1 ovarian cancer cells when used at low micromolar concentrations in combination with 17β-estradiol.{37610} It also increases tumor mass in a BG-1 ovariectomized mouse xenograft model after 70 days when administered at a dose of 3 mg/kg every three days. Formulations containing cyprodinil have been used in the control of fungi in agriculture.  

 

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Description

An anilinopyrimidine fungicide; inhibits the biosynthesis of methionine in phytopathogenic fungi; inhibits mycelial cell growth of B. cinerea, P. herpotrichoides, and H. oryzae on amino acid-free media (IC50s = 0.44, 4.8, and 0.03 µM, respectively); an estrogen receptor agonist (EC20 = 1.91 µM); inhibits the androgenic effect of DHT (IC20 = 15.1 µM); increases proliferation of estrogen receptor-expressing BG-1 ovarian cancer cells at low micromolar concentrations in combination with 17β-estradiol; increases tumor mass in a BG-1 ovariectomized mouse xenograft model after 70 days at 3 mg/kg every three days

Formal name: 4-cyclopropyl-6-methyl-N-phenyl-2-pyrimidinamine

Synonyms: 

Molecular weight: 225.3

CAS: 121552-61-2

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Pesticides|Fungicides||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cancer||Research Area|Endocrinology & Metabolism|Hormones & Receptors||Research Area|Endocrinology & Metabolism|Reproductive Biology||Research Area|Toxicology|Environmental|Agriculture||Research Area|Toxicology|Environmental|Endocrine Disruption||Research Area|Toxicology|Environmental|Steroids

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